Virucidal Short Wavelength Ultraviolet Light Treatment of Plasma and Factor VI 11 Concentrate : Protection of Proteins by Antioxidants
نویسندگان
چکیده
The use of solvent/detergent mixtures and various forms of heat treatment to inactivate viruses has become widespread in the preparation of blood derivatives. Because viruses that lack lipid envelopes and/or are heat resistant, eg, hepatitis A virus (HAV) or parvovirus B19 may be present, the use of two methods of virus elimination that operate by different mechanisms has been advocated. We now report on short wavelength ultraviolet light (UVC) irradiation for virus inactivation and enhancement of its compatibility with proteins by quenchers of reactive oxygen species (ROS). Treatment of an antihemophilic factor (AHF) concentrate or whole plasma with 0.1 J/cm2 inactivated 10' t o 2 10' infectious doses (ID) of encephalomyocarditis virus (EMCV), HAV, bacteriophage M13, vesicular stomatitis virus (VSV), and porcine parvovirus. However, the recovery of factor Vlll was 30% or lower
منابع مشابه
Virucidal short wavelength ultraviolet light treatment of plasma and factor VIII concentrate: protection of proteins by antioxidants.
The use of solvent/detergent mixtures and various forms of heat treatment to inactivate viruses has become widespread in the preparation of blood derivatives. Because viruses that lack lipid envelopes and/or are heat resistant, eg, hepatitis A virus (HAV) or parvovirus B19 may be present, the use of two methods of virus elimination that operate by different mechanisms has been advocated. We now...
متن کاملNitrogen Gas Plasma Generated by a Static Induction Thyristor as a Pulsed Power Supply Inactivates Adenovirus
Adenovirus is one of the most important causative agents of iatrogenic infections derived from contaminated medical devices or finger contact. In this study, we investigated whether nitrogen gas plasma, generated by applying a short high-voltage pulse to nitrogen using a static induction thyristor power supply (1.5 kilo pulse per second), exhibited a virucidal effect against adenoviruses. Viral...
متن کاملHydrogen sulfide and organic compounds removal in municipal wastewater using ferrate (VI) and ultraviolet radiation
Background: In this study, ferrate (VI) and ultraviolet (UV) radiation were employed to remove hydrogen sulfide from municipal wastewater resulting in a reduction in chemical oxygen demand (COD). Although ferrate (VI) and UV have been used individually for the removal of a few pollutants from urban and industrial wastewater, there exists no study to investigate the effectiveness of si...
متن کاملBlocking Short-Wavelength Component of the Visible Light Emitted by Smartphones’ Screens Improves Human Sleep Quality
Background: It has been shown that short-wavelength blue component of the visible light spectrum can alter the circadian rhythm and suppress the level of melatonin hormone. The short-wavelength light emitted by smartphones’ screens can affect the sleep quality of the people who use these devices at night through suppression of melatonin.Objectives: In this study, we examined the effects of co...
متن کاملComparison of Ultraviolet Protection Factor of Pure Cotton and Cotton Coated with Titanium Dioxide Nanoparticles using the Electrospinning Method with Two Ultraviolet-C Generators
Introduction: Protection against harmful effects of ultraviolet radiation (UV) is measured under Ultraviolet Protection Factor (UPF) scale. The utilization of protective clothing is the best way to deal with the damage caused by ultraviolet radiation. The purpose of this study was to compare the ultraviolet ray protective factor of pure cotton and cotton coated with ti...
متن کامل